منابع مشابه
Cell migration during morphogenesis.
During development, functional structures must form with the correct three-dimensional geometry composed of the correct cell types. In many cases cell types are specified at locations distant to where they will ultimately reside for normal biological function. Although cell migration is crucial for normal development and morphogenesis of animal body plans and organ systems, abnormal cell migrat...
متن کاملEngineered tissues to quantify collective cell migration during morphogenesis.
Renal development is a complex process involving the dynamic interplay of over 25 different cell types. One distinct step in this process is the formation of the ureteric tree, which develops from the repeated branching of the ureteric bud. During branching of the ureteric bud, cells migrate collectively in unison to form the complex structure of the tree. Here, we present a microlithography-ba...
متن کاملCollective cell migration in morphogenesis and cancer.
The movement of cells that maintain cell-cell junctions yet protrude along or within tissues is an important mechanism for cell positioning in morphogenesis, tissue repair and cancer. Collective cell migration shares similarities but also important differences to individually migrating cells. Coherent groups of cells are arranged and held together by cell-cell adhesion molecules, including cadh...
متن کاملCell signalling during vascular morphogenesis.
Vascular tissue in plants is unique due to its diverse and dynamic cellular patterns. Through research in several organisms, such as Arabidopsis, Populus and Zinnia, using biochemical, genetic and genomic approaches, significant progress has recently been made in revealing the molecular nature of several signals underlying the patterning of vascular tissue. These signals include ligands, recept...
متن کاملCortactin modulates cell migration and ring canal morphogenesis during Drosophila oogenesis
Cortactin is a Src substrate that interacts with F-actin and can stimulate actin polymerization by direct interaction with the Arp2/3 complex. We have isolated complete loss-of-function mutants of the single Drosophila cortactin gene. Mutants are viable and fertile, showing that cortactin is not an essential gene. However, cortactin mutants show distinct defects during oogenesis. During oogenes...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2010
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2009.11.014